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Human SSTR2 Full Length Protein (VLP)

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Product Number/Spec
Price
Menge
SS2-H5216-20ug
$620.00
SS2-H5216-100ug
$1235.00
SS2-H5216-500ug
$4305.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonym

    Smstr2, Somatostatin R2, somatostatin receptor 2, somatostatin receptor type 2, SomatostatinR2, SRIF-1, SS2R, SS-2-R, SS2-R, SST2, SSTR2

  • Source

    Human SSTR2 Full Length Protein-VLP (SS2-H5216) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ile 369 (Accession # P30874-1).

    Predicted N-terminus: Asp

  • Molecular Characterization

    Virus-like particles(VLPs) are formed by self-assembly of capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SEC-HPLC.

  • Formulation

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.

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Data Display

  • SEC-HPLC

    SSTR2 SEC-HPLC

    The purity of Human SSTR2 Full Length Protein-VLP (Cat. No. SS2-H5216) was greater than 95% as determined by SEC-HPLC.

  • Bioactivity-ELISA

     SSTR2 ELISA

    Immobilized Human SSTR2 Full Length Protein-VLP (Cat. No. SS2-H5216) at 5 μg/mL (100 μL/well) can bind Anti-SSTR2 Antibody, Human IgG1 with a linear range of 0.3-5 ng/mL (QC tested).

    Protocol

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Publish Comment

Background Introduction

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Somatostatin receptor 2

  • Category:

  • Listed Drugs Count:

    7 Details

  • Clinical Drugs Count:

    29 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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