Tau

Tau Molekülinformation

Englischer Name	Microtubule-associated protein tau	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	36	Target-Alias	MAPT，MTBT1，Paired helical filament-tau，MAPTL，Microtubule Associated Protein Tau，G Protein Beta1/Gamma2 Subunit-Interacting Factor 1，Protein Phosphatase 1， Regulatory Subunit 103，Neurofibrillary Tangle Protein，PHF-Tau，TAU，Microtubule-Associated Protein Tau， Isoform 4，Microtubule-Associated Protein Tau，PPP1R103，FTDP-17，MTBT2，DDPAC，MSTD，PPND，tau Proteins，MGC138549，FLJ31424
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Microtubule-associated protein tau
Target-Alias	MAPT，MTBT1，Paired helical filament-tau，MAPTL，Microtubule Associated Protein Tau，G Protein Beta1/Gamma2 Subunit-Interacting Factor 1，Protein Phosphatase 1， Regulatory Subunit 103，Neurofibrillary Tangle Protein，PHF-Tau，TAU，Microtubule-Associated Protein Tau， Isoform 4，Microtubule-Associated Protein Tau，PPP1R103，FTDP-17，MTBT2，DDPAC，MSTD，PPND，tau Proteins，MGC138549，FLJ31424
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	36
Höchste Forschungs- und Entwicklungsphase	Approved

Tau Produktliste

Attribut
Protein (18)Cell (1)Antibody (2)
Produktbibliothek
Online (21)
Spezies
Human (18)Cynomolgus (1)Mouse (2)
Etikett
His Tag (7)Tag Free (11)GFP Tag (1)- (1)Mouse IgG1 (1)
Marker
Unconjugated (20)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CHEK-ATP087	Human	HEK293	HEK293/Human Tau-K18 (GFP) Stable Cell Line	In den Warenkorb legen
HOT TAU-H5113	Human	E. coli	Human Tau-441 K18 (P301L) Pre-formed Fibrils Protein, Tag Free	In den Warenkorb legen
HOT TAU-H5115	Human	E. coli	Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free	In den Warenkorb legen
HOT TAU-H5117	Human	E. coli	Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (MALS verified)	In den Warenkorb legen
HOT TAU-H51H3	Human	E. coli	Human Tau-441 / 2N4R Protein, His Tag	In den Warenkorb legen
TAU-H5112	Human	E. coli	Human Tau-381 / 1N3R Protein, Tag Free (MALS verified)	In den Warenkorb legen
TAU-H5114	Human	E. coli	Human Tau Protein, Tag Free, low endotoxin (MALS verified)	In den Warenkorb legen
TAU-H5116	Human	E. coli	Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free	In den Warenkorb legen
TAU-H5118	Human	E. coli	Human Tau-441 (K18, P301L) Protein, Tag Free, low endotoxin (MALS verified)	In den Warenkorb legen
TAU-H5119	Human	E. coli	Human Tau-412 / 1N4R Protein, Tag Free, low Endotoxin (MALS verified)	In den Warenkorb legen

Gesamtmenge21

Tau Molekülhintergrund

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Tau Molekülalias

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Down Syndrome; Chronic Traumatic Encephalopathy; Alzheimer Disease; Parkinson Disease; Cognitive Dysfunction; Frontotemporal Dementia	Details
Florzolotau (Aprinoia Therapeutics)	[18F]PM-PBB3; APN-1607; 18F-PM-PBB3; 18F-APN-1607; [18F]APN-1607; [18F]MNI-958; APN-0000455; F0-PBB3; PM-PBB3	Phase 3 Clinical	Aprinoia Therapeutics Ltd	Supranuclear Palsy, Progressive; Nerve Degeneration; Alzheimer Disease; Cognitive Dysfunction; Diagnostic agents; Cognition Disorders	Details
E-2814	E-2814	Phase 3 Clinical	Eisai Co Ltd	Dementia; Alzheimer Disease	Details
Izaflortaucipir F-18	PI-2620; 18F-PI-2620; [18F]PI-2620	Phase 3 Clinical	Piramal, Ac Immune Sa	Supranuclear Palsy, Progressive; Brain Injuries, Traumatic; Opioid-Related Disorders; Frontotemporal Lobar Degeneration; Alzheimer Disease; Cognitive Dysfunction	Details
XTR-006	XTR-006	Phase 3 Clinical	Beijing Xiantong International Technology Co Ltd	Tauopathies; Alzheimer Disease	Details
Zagotenemab	LY-3303560	Phase 2 Clinical	Eli Lilly And Company	Alzheimer Disease	Details
Posdinemab	JNJ-3657; JNJ-63733657	Phase 2 Clinical	Johnson & Johnson Innovative Medicine	Dementia; Alzheimer Disease; Cognitive Dysfunction	Details
[18F]GTP-1	[18F]GTP-1	Phase 2 Clinical	Genentech Inc	Alzheimer Disease	Details
[18F]THK-5105	[18F]THK-5105	Phase 2 Clinical	Tohoku University	Alzheimer Disease	Details
ISIS-814907	BIIB-080; ISIS-814907; IONIS-MAPTRx; ISIS-BIIB4Rx; IONIS-BIIB4RX	Phase 2 Clinical	Biogen Inc, Ionis Pharmaceuticals Inc	Dementia; Cognitive Dysfunction; Alzheimer Disease	Details
Tilavonemab	C2N-8E12; ABBV-8E12	Phase 2 Clinical	C2n Diagnostics Llc	Supranuclear Palsy, Progressive; Alzheimer Disease	Details
Semorinemab	MTAU-9937A; MTAU9937A; RG-6100; RO7105705; RO-7105705	Phase 2 Clinical	Ac Immune Sa	Alzheimer Disease	Details
APN-1701	[18F]AM-PBB3; 18F-AM-PBB3; APN-1701	Phase 2 Clinical	National Institute Of Radiological Sciences, Aprinoia Therapeutics Ltd	Nerve Degeneration; Alzheimer Disease	Details
VY-TAU-01	VY-TAU01; VY-TAU-01; VY-7523	Phase 2 Clinical	Voyager Therapeutics Inc	Alzheimer Disease	Details
Anti-tau antibody (Prothena)	PRX-005; BMS-986446	Phase 2 Clinical	Prothena	Alzheimer Disease; Frontotemporal Dementia	Details
Bepranemab	UCB-0107; RG6416	Phase 2 Clinical	Ucb	Supranuclear Palsy, Progressive; Alzheimer Disease	Details
[18F]THK-5117	[18F]THK-5117	Phase 2 Clinical	Tohoku University	Alzheimer Disease	Details
PNT-001	PNT-001	Phase 1 Clinical	Beth Israel Deaconess Medical Center	Brain Injuries, Traumatic; Alzheimer Disease	Details
ReS19-T	ReS19-T	Phase 1 Clinical	Remynd	Alzheimer Disease	Details
Mecripyrine Hydrochloride	SCR-1693; Y-1A; Y-1	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd, NeuroDawn Pharmaceutical Co Ltd	Brain Neoplasms; Alzheimer Disease	Details
Lu-AF87908	Lu-AF87908; Lu-AF-87908	Phase 1 Clinical	H. Lundbeck A/S	Alzheimer Disease	Details
RDC-5	RDC-5	Phase 1 Clinical	Chronos Therapeutics Ltd	Amyotrophic Lateral Sclerosis	Details
MC-1 (Lilly)	MC-1 (Lilly)	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	Details
OLX-07010	OLX07010	Phase 1 Clinical	Oligomerix Inc	Supranuclear Palsy, Progressive; Alzheimer Disease; Dementia; Neurodegenerative Diseases	Details
Protollin		Phase 1 Clinical		Alzheimer Disease	Details
AB-19 (AUTOTAC Bio)	AB-19 (AUTOTAC Bio)	Phase 1 Clinical	Autotac Bio Inc	Supranuclear Palsy, Progressive	Details
AB-12 po (AUTOTAC Bio)	AB-12 po	Phase 1 Clinical	Autotac Bio Inc	Alzheimer Disease	Details
[89Zr]Zr-DFO-BIIB080	[89Zr]Zr-DFO-ISIS-814907; [89Zr]Zr-DFO	Phase 1 Clinical	Biogen Inc		Details
DA-7503	DA-7503	Phase 1 Clinical	Dong-A ST Co Ltd		Details
LY-3954068	LY3954068; LY-3954068	Phase 1 Clinical	Eli Lilly And Company	Alzheimer Disease	Details
ADEL-Y01	ADEL-Y01	Phase 1 Clinical	Oscotec Inc, ADEL Inc	Tauopathies; Alzheimer Disease	Details
MK-2214	MK-2214	Phase 1 Clinical	Merck Sharp & Dohme LLC	Alzheimer Disease	Details
APNmAb-005	APNmAb-005	Phase 1 Clinical	Aprinoia Therapeutics Ltd	Nerve Degeneration; Alzheimer Disease; Tauopathies	Details
NIO-752	NIO-752	Phase 1 Clinical	Novartis Pharma Ag	Supranuclear Palsy, Progressive; Alzheimer Disease; Cognitive Dysfunction; Neurodegenerative Diseases	Details
BEY-2153	BEY-2153	Phase 1 Clinical	Beyondbio Inc	Alzheimer Disease	Details
11C-PBB3	11C-PBB3	Clinical	National Institute Of Radiological Sciences	Alzheimer Disease	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Flortaucipir F18	18F-AV-1451; [F18]AV1451; LY3191748; F-18-AV-1451; [18F]-T-807; [3H]AV 1451; T807; [F-18]T807	Approved	Siemens Medical Solution	Tauvid	United States	Alzheimer Disease	Avid Radiopharmaceuticals Inc	2020-05-28	Dementia; Frontotemporal Dementia; Neurodegenerative Diseases; Cognition Disorders; Corticobasal degeneration; Diagnostic agents; Cognitive Dysfunction; Tauopathies; Parkinson Disease; Supranuclear Palsy, Progressive; Alzheimer Disease; Pick Disease of the Brain; Aphasia, Primary Progressive; Chronic Traumatic Encephalopathy; Brain Concussion; Brain Injuries, Traumatic; Depression; Brain Injuries	Details

Produktrezensionen

P***g2021-08-24
5Menschen mögen
Human Tau-441 / 2N4R Protein, His Tag
I have purchased multiple antigens from ACRO for discovery projects and I have found that the quality of antigens purchased from Acro is great!! Acro has become by go to vendor when I am looking for quality antigens. In addition, Acro also provides an impressive range of formats for each antigens, including different tags. Not to mention, their customer service team is fantastic. Overall, a great company to work with.