NOTCH1

NOTCH1 Molekülinformation

Englischer Name	Neurogenic locus notch homolog protein 1	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Neurogenic locus notch homolog protein 1
Target-Alias	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

NOTCH1 Produktliste

Attribut
Protein (4)
Produktbibliothek
Online (4)
Spezies
Mouse (1)Human (3)
Etikett
His Tag (2)Fc Tag (2)
Marker
Unconjugated (3)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT NO1-H52H3	Human	HEK293	Human NOTCH1 Protein, His Tag, premium grade	In den Warenkorb legen
NO1-H5255	Human	HEK293	Human NOTCH1 Protein, Fc Tag (MALS verified)	In den Warenkorb legen
NO1-H8253	Human	HEK293	Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling)	In den Warenkorb legen
NO1-M52H8	Mouse	HEK293	Mouse NOTCH1 Protein, His Tag	In den Warenkorb legen

Gesamtmenge4

NOTCH1 Molekülhintergrund

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1 Molekülalias

NOTCH1,Notch 1,hN1,TAN1

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Crenigacestat	JSMD-194; LY-3039478; BMS-986405	Phase 2 Clinical	Eli Lilly And Company	Breast Neoplasms; Neoplasm Metastasis; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Hepatocellular; Lymphoma; Lymphoma, T-Cell; Leukemia, B-Cell; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Cholangiocarcinoma; Sarcoma; Multiple Myeloma; Carcinoma, Adenoid Cystic; Colonic Neoplasms; Triple Negative Breast Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell	Details