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Product Details
Synonym
GPRC5D, G-protein coupled receptor family C group 5 member D
Source
Mouse GPRC5D Full Length Protein (VLP) (GPD-M52P3) is expressed from human 293 cells (HEK293). It contains AA Tyr 2 - Leu 344 (Accession # Q9JIL6-1).
Predicted N-terminus: Asp
Molecular Characterization
Virus-like particles(VLPs) are formed by self-assembly of capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.
Formulation
The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Shipping
This product is supplied and shipped with dry ice, please inquire the shipping cost.
Storage
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 12 months under sterile conditions.
ACRO Quality Management System
- *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.
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Data Display
Bioactivity-ELISA
Immobilized Mouse GPRC5D Full Length Protein (VLP) (Cat. No. GPD-M52P3) at 5 μg/mL (100 μL/well) can bind Anti-GPRC5D Antibody with a linear range of 0.04-1.25 μg/mL (QC tested).
Protocol
Identity-DLS
The mean peak Radius of VLP is 50-75 nm with more than 95% intensity as determined by dynamic light scattering (DLS).
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Background Introduction
Frontier Progress
Drug Development Progress- English Name：
G-protein coupled receptor family C group 5member D
- Category：
- Listed Drugs Count：
1 Details
- Clinical Drugs Count：
38 Details
- Highest R&D Stage：
Approved
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