Human GCGR Protein, Flag,His Tag (Detergent)

Customer Reviews
Cat. No. / Size
Price
Qty
GCR-H52D3-20ug
$805.00
GCR-H52D3-100ug
$2985.00
GCR-H52D3-500ug
$7480.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    Glucagon R, GCGR, Glucagon receptor

  • Source

    Human GCGR Protein, Flag,His Tag (GCR-H52D3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 256 & Glu 260 - Asn 432 (Accession # P47871-1).

    Predicted N-terminus: Asp

    Request for sequence
  • Molecular Characterization

    This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 83.2 kDa.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Formulation

    This product is not suitable for cell based experiments due to cytotoxicity of DDM.
    DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove DDM and CHS.
    DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
    If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • *The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow this link for product information.

Customers Also Viewed

Performance Data

  • Bioactivity-ELISA

     GCGR ELISA

    Immobilized Human GCGR Protein, Flag,His Tag (Cat. No. GCR-H52D3) at 5 μg/mL (100 μL/well) on a Nickel Coated plate can bind Monoclonal Anti-Human GCGR antibody, Human IgG2 (Volagidemab) (Cat. No. GCR-H52D3) with a linear range of 0.1-3 ng/mL (QC tested).

    Protocol
  •  GCGR ELISA

    Immobilized Human GCGR Protein, Flag,His Tag (Cat. No. GCR-H52D3) at 5 μg/mL (100 μL/well) on a Nickel Coated plate can bind Monoclonal Anti-Human GCGR antibody, Human IgG4 (Crotedumab) with a linear range of 0.1-3 ng/mL (Routinely tested).

    Protocol

Customer Reviews
Writing Reviews

Background

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

Recent Advances

 
Drug Development Progress
  • English Name:

    Glucagon receptor

  • Category:

  • Approved Drugs:

    6 Details

  • Drugs in Clinical Trials:

    40 Details

  • Highest Development Stage:

    Approved

Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Customers Also Viewed
  • Performance Data
  • Customer Reviews
  • Background