Human Cadherin-17 / CDH17 Protein, Fc Tag

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Cat. No. / Size
Price
Qty
CA7-H5254-100ug
$245.00
CA7-H5254-1mg
$1340.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    Cadherin-17, CDH17, HPT-1, LI-cadherin

  • Source

    Human Cadherin-17 Protein, Fc Tag (CA7-H5254) is expressed from human 293 cells (HEK293). It contains AA Ala 668 - Gly 777 (Accession # Q12864-1).

    Predicted N-terminus: Ala 668

    Request for sequence
  • Molecular Characterization

    Cadherin-17 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 38.6 kDa. The protein migrates as 42-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Cadherin-17 SDS-PAGE

    Human Cadherin-17 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Cadherin-17 ELISA

    Immobilized Human Cadherin-17 Protein, Fc Tag (Cat. No. CA7-H5254) at 1 μg/mL (100 μL/well) can bind various dilution ratio of Anti-Cadherin 17/CDH17 Antibody, Mouse IgG2a (QC tested).

    Protocol

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Background

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Recent Advances

 
Drug Development Progress
  • English Name:

    Cadherin-17

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    17 Details

  • Highest Development Stage:

    Phase 2 Clinical

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  • Background