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PAR2

PAR2 Overview

English Name	Protease-activated receptor-2	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	Receptor， PAR-2，F2RL1，Thrombin receptor-like 1，G-protein coupled receptor 11，F2R Like Trypsin Receptor 1，PAR2，GPR11，Protease-Activated Receptor 2，Coagulation Factor II (Thrombin) Receptor-Like 1，Proteinase-Activated Receptor-2，Proteinase-activated receptor 2，Coagulation factor II receptor-like 1
Highest Development Stage	Phase 2 Clinical

English Name	Protease-activated receptor-2
Target Synonym	Receptor， PAR-2，F2RL1，Thrombin receptor-like 1，G-protein coupled receptor 11，F2R Like Trypsin Receptor 1，PAR2，GPR11，Protease-Activated Receptor 2，Coagulation Factor II (Thrombin) Receptor-Like 1，Proteinase-Activated Receptor-2，Proteinase-activated receptor 2，Coagulation factor II receptor-like 1
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

PAR2 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
- (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
PA2-H52P7	Human	HEK293	Human PAR2 Full Length Protein (VLP)

Total: 1

PAR2 Background

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

PAR2 Synonyms

PAR2

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
MEDI-0618	MEDI-0618	Phase 2 Clinical	Astrazeneca Plc	Migraine Disorders; Chronic Pain	Details
TEV-56192	TEV-56192	Phase 1 Clinical	Teva Pharmaceutical Industries Ltd	Nervous System Diseases	Details
OA-235i	OA-235i	Phase 1 Clinical	Oasis Pharmaceuticals LLC	Metabolic Dysfunction-Associated Steatotic Liver Disease	Details