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Home PageAll MoleculesLY75
LY75
LY75 Overview
| English Name | Lymphocyte antigen 75 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 | Target Synonym | LY75，CD205，Lymphocyte Antigen 75，C-Type Lectin Domain Family 13 Member B，CLEC13B，DEC-205，CD205 Antigen，Gp200-MR6，Ly-75 |
| Highest Development Stage | Phase 1 Clinical | ||
| English Name | Lymphocyte antigen 75 |
| Target Synonym | LY75，CD205，Lymphocyte Antigen 75，C-Type Lectin Domain Family 13 Member B，CLEC13B，DEC-205，CD205 Antigen，Gp200-MR6，Ly-75 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 2 |
| Highest Development Stage | Phase 1 Clinical |
LY75 Product List
- Product Category
Protein (2)
- Product Status
Launched (2)
- Species
Mouse (1)Human (1)
- Tag
His Tag (2)
- Conjugate
Unconjugated (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
LY5-H52H3 |  Human | HEK293 | Human LY75 / CD205 Protein, His Tag |  |  | |
LY5-M52H5 |  Mouse | HEK293 | Mouse LY75 / CD205 Protein, His Tag (MALS verified) |  | |
Total: 2
- 1
LY75 Background
lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.
LY75 Synonyms
LY75,CD205,DEC-205,CLEC13B,Lymphocyte antigen 75,gp200-MR6
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Rasdegafusp alfa | CDX-1401 | Phase 2 Clinical | Ludwig Institute For Cancer Research | Sarcoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Carcinoma, Endometrioid; Melanoma; Leukemia, Myeloid, Acute; Fallopian Tube Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Uterine Neoplasms; Peritoneal Neoplasms; Astrocytoma; Colorectal Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Skin Melanoma; Uveal melanoma; Oligodendroglioma; Urinary Bladder Neoplasms; Hormone-Resistant Prostate Neoplasms; Carcinoma, Ovarian Epithelial; Neoplasms; Anemia, Refractory; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Colonic Neoplasms; Glioblastoma; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Ovarian Neoplasms | Details |
| Oberotatug ravtansine | OBT-076; MEN1309/OBT076; MEN-1309 | Phase 1 Clinical | Oxford Biotherapeutics Ltd, Menarini | Solid tumours; Head and Neck Neoplasms; Carcinoma, Adenoid Cystic; Lymphoma, Non-Hodgkin | Details |
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