IL-6

IL-6 Molekülinformation

Englischer Name	Interleukin-6	Anzahl der inverkehr gebrachten Arzneimittel	6
Anzahl der klinischen Arzneimittel	22	Target-Alias	CTL Differentiation Factor，Interleukin 6 (Interferon， Beta 2)，HSF，B-cell stimulatory factor 2，Interferon beta-2，IL6，IFNB2，IL-6，Interleukin-6，Interleukin 6，Hybridoma Growth Factor，IFN-Beta-2，BSF-2，CDF，B-Cell Differentiation Factor，Interferon， Beta 2，Interleukin BSF-2，BSF2，HGF
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Interleukin-6
Target-Alias	CTL Differentiation Factor，Interleukin 6 (Interferon， Beta 2)，HSF，B-cell stimulatory factor 2，Interferon beta-2，IL6，IFNB2，IL-6，Interleukin-6，Interleukin 6，Hybridoma Growth Factor，IFN-Beta-2，BSF-2，CDF，B-Cell Differentiation Factor，Interferon， Beta 2，Interleukin BSF-2，BSF2，HGF
Anzahl der inverkehr gebrachten Arzneimittel	6
Anzahl der klinischen Arzneimittel	22
Höchste Forschungs- und Entwicklungsphase	Approved

IL-6 Produktliste

Attribut
Protein (10)Kits (6)
Produktbibliothek
Online (16)
Spezies
Human (10)Mouse (4)Cynomolgus (2)
Etikett
Tag Free (4)His Tag (3)His Tag & Avi Tag (3)- (6)
Marker
Unconjugated (6)Biotin-labeled (4)- (6)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CRS-B001	Human	-	Human IL-6 ELISA Kit	In den Warenkorb legen
HOT GMP-L06H27	Human	HEK293	GMP Human IL-6 Protein	In den Warenkorb legen
HOT IL6-H4218	Human	HEK293	Human IL-6 Protein, premium grade	In den Warenkorb legen
HOT IL6-H5243	Human	HEK293	Human IL-6 Protein, His Tag (MALS verified)	In den Warenkorb legen
HOT IL6-H82Q9	Human	HEK293	Biotinylated Human IL-6 Protein, Avitag™,His Tag (MALS verified)	In den Warenkorb legen
HOT IL6-C5249	Cynomolgus	HEK293	Cynomolgus IL-6 Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
CRS-A005	Human	-	resDetect™ Human Interleukin-6 (IL-6) ELISA Kit (Residue Testing)	In den Warenkorb legen
EP-146	Human	-	IL-6 [Biotinylated] : IL-6 R alpha Inhibitor Screening ELISA Kit	In den Warenkorb legen
FCSh-003	Human	-	Human IL-6 Detection Kit (Flow Cytometry Bead Assay)	In den Warenkorb legen
IL6-H5115	Human	E. coli	Human IL-6 Protein (E. coli), premium grade	In den Warenkorb legen

Gesamtmenge16

IL-6 Molekülhintergrund

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

IL-6 Molekülalias

IL6,Interleukin-6,BSF2,HSF,IFNB2

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Ensereptide	PXL-01	Phase 3 Clinical	Promore Pharma	Tissue Adhesions; Post-surgical adhesions; Cicatrix	Details
Olokizumab	CDP-6038; Anti-IL6-UCB	Phase 3 Clinical	Ucb	Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Lung Diseases, Interstitial; Arthritis; Crohn Disease	Details
Efprezimod alfa	CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110	Phase 3 Clinical	Oncoimmune Inc	HIV Infections; Hematopoietic stem cell transplantation (HSCT); Solid tumours; Leukemia; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Dyslipidemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Melanoma	Details
Ziltivekimab	EX-6018; MEDI-5117; WBP-216; COR-001; NN6018	Phase 3 Clinical	Medimmune Llc	Atherosclerosis; Myocardial Infarction; Heart Failure; Anemia; Arthritis, Rheumatoid; Cardiovascular Diseases; Renal Insufficiency, Chronic; Inflammation; Systemic Inflammatory Response Syndrome	Details
Clazakizumab	BMS-645429; ALD518-003; ALD-518; CSL300; BMS-945429; CSL-300	Phase 3 Clinical	Alder Biopharmaceuticals	Cardiovascular Diseases; Stomatitis; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Diabetes Mellitus; Kidney Failure, Chronic; Cachexia; Asthma; Arthritis, Psoriatic; Plaque, Atherosclerotic; Rejection of organ transplantation; Graft vs Host Disease; Arthritis, Rheumatoid; Fatigue; Coronavirus Disease 2019 (COVID-19); Atherosclerosis; Myocardial Infarction	Details
Tabirafusp tedromer	KSI-501ABC; KSI-501	Phase 3 Clinical	Kodiak Sciences Inc	Retinal Diseases; Wet Macular Degeneration; Diabetic macular oedema; Uveitis	Details
Bezisterim	HE-3286; NE-3107	Phase 3 Clinical	Harbor Therapeutics, Biovie Inc	Diabetes Mellitus, Type 2; Brain Injuries, Traumatic; Insulin Resistance; Arthritis, Rheumatoid; Post-Acute COVID-19 Syndrome; Alzheimer Disease; Parkinson Disease; Colitis, Ulcerative	Details
Vamikibart	RO-7200220; RG-6179; EBI-031	Phase 3 Clinical	Sesen Bio Inc	Macular Edema; Diabetic macular oedema	Details
Sodium Hypochlorite		Phase 3 Clinical		Cystic Fibrosis; Pulpitis; Infections; Pain; Pain, Postoperative; Fibrosis; Dental Pulp Necrosis	Details
PF-04236921	PF-04236921; TOUR006; TOUR-006; PF-4236921	Phase 2 Clinical	Pfizer Inc	Arthritis, Rheumatoid; Graves Ophthalmopathy; Lupus Erythematosus, Systemic; Cardiovascular Diseases; Renal Insufficiency, Chronic; Crohn Disease	Details
Sirukumab	BA-003; CNTO-136	Phase 2 Clinical	Glaxosmithkline Plc, Johnson & Johnson Innovative Medicine	Depressive Disorder, Major; Giant Cell Arteritis; Arthritis, Rheumatoid; Lupus Erythematosus, Cutaneous; Coronavirus Disease 2019 (COVID-19); Lupus Nephritis; Polymyalgia Rheumatica; Lupus Erythematosus, Systemic; Asthma	Details
KSI-101	KSI-501P; KSI-101	Phase 2 Clinical	Kodiak Sciences Inc	Macular Edema	Details
Anti-interleukin-6 receptor monoclonal antibody (Biocad)		Phase 2 Clinical	BIOCAD JSC	Autoimmune Diseases	Details
Isomyosamine	MYMD-1	Phase 2 Clinical	Mymd Pharmaceuticals Inc	Anxiety; Frailty; Hashimoto Disease; Depression; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia	Details
FB-704A	FB-704; FB-704A	Phase 2 Clinical	Fountain Biopharma Inc	Arthritis, Rheumatoid; Asthma	Details
Gerilimzumab	GB-224; RYI-008; ARGX-109	Phase 1 Clinical	Argenx Se	Arthritis, Rheumatoid	Details
Tocilizumab biosimilar (Mycenax Biotech)		Phase 1 Clinical	Mycenax Biotech Inc	Arthritis, Rheumatoid	Details
GFS-202-A	GFS-202-A; GFS202A	Phase 1 Clinical	Genfleet Therapeutics (Shanghai) Co Ltd	Cachexia	Details
SCD-153	SCD-153	Phase 1 Clinical	Sun Pharma Advanced Research Company Ltd, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Johns Hopkins University	Alopecia Areata	Details
NEX-20A	NEX-20A	Phase 1 Clinical	Nanexa AB	Multiple Myeloma	Details
Luxeptinib	CG026806; CG-806; CG’806; CG-026806	Phase 1 Clinical	Crystalgenomics Inc	Hematologic Neoplasms; Myelodysplastic Syndromes; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell	Details
Wogonin			Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University		Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Lenalidomide	CC-5013; IMiD-3; ENMD-0997; STAR-LLD; IMID-5013; CDC-5013; CDC-501	Approved	Celgene Corp	Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo, Zelvina	United States	Myelodysplastic Syndromes	Bristol Myers Squibb Srlcompany	2005-12-27	Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Solid tumours; Bone Marrow Neoplasms; Kidney Neoplasms; Leukemia, Myeloid; Leukemia; Intestinal Neoplasms; Craniopharyngioma; Optic Nerve Glioma; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Medulloblastoma; Ependymoma; Immunoproliferative Small Intestinal Disease; Leukemia, Erythroblastic, Acute; Hematologic Diseases; Liver Neoplasms; Plaque, Amyloid; Anemia; Pain; Paraproteinemias; Polycythemia Vera; Anemia, Refractory, with Excess of Blasts; Rhabdoid Tumor; Leukemia, Hairy Cell; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Hodgkin Disease; Graft vs Host Disease; Glioblastoma; Neoplasms; Blood Protein Disorders; Nerve Degeneration; Anemia, Refractory; Hypothalamic Neoplasms; Leukemia, Myelomonocytic, Acute; Pancreatic Neoplasms; Lymphomatoid Granulomatosis; Smoldering Multiple Myeloma; Multiple Myeloma; Urinary Bladder Neoplasms; Central Nervou	Details
Luminol sodium	MP-1032	Approved	Selvim, Metrio			Psoriasis; Immune System Diseases	null	1997-01-01	Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis; Plaque psoriasis	Details
Pomalidomide	CDC-394; CC-4047; IMiD-1; IMID-4047	Approved	Celgene Corp	Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃	United States	Multiple Myeloma	Bristol-Myers Squibb Company	2013-02-08	Lung Diseases, Interstitial; Neurofibromatosis 1; Atypical Squamous Cells of the Cervix; Sarcoma, Kaposi; Anemia, Sickle Cell; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Glioma; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Prostatic Neoplasms; Thrombocytosis; Sarcoma; Central Nervous System Neoplasms; Pulmonary Fibrosis; Medulloblastoma; Multiple Myeloma; Pancreatic Neoplasms; Hodgkin Disease; Plasmacytoma; Myeloproliferative Disorders; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Scleroderma, Systemic; Renal Insufficiency; Polycythemia Vera; Bone Marrow Neoplasms; Solid tumours; Optic Nerve Glioma	Details
Siltuximab	cCLB-8; CNTO-328	Approved	Johnson & Johnson	Sylvant	United States	Multicentric Castleman's Disease (MCD)	Eusa Pharma	2014-04-23	Immunoglobulin Light-chain Amyloidosis; Leukemia, Large Granular Lymphocytic; Thrombocytopenia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Primary Myelofibrosis; Castleman Disease; Colorectal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms, Plasma Cell; Prostatic Neoplasms; Multicentric Castleman's Disease (MCD); Monoclonal Gammopathy of Undetermined Significance; Lung Diseases; Multiple Myeloma; Respiratory Distress Syndrome, Adult; Bone Marrow Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Psychotic Disorders; Respiratory Tract Diseases; Smoldering Multiple Myeloma; Polycythemia Vera; Carcinoma, Renal Cell; Pneumonia; Schizophrenia; Diabetes Mellitus, Type 1; Ovarian Neoplasms; Cytokine Release Syndrome; Head and Neck Neoplasms; Respiratory Tract Infections; Kidney Neoplasms	Details
Andrographolide/Sodium Hydrogen Sulfite		Approved							Bacterial Infections	Details
Thalidomide	NSC-66847; NSC-527179; K-17; FPF-300; FPF300	Approved	Celgene Corp	Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled	Mainland China	Leprosy, Lepromatous; Multiple Myeloma	Changzhou Pharmaceutical Factory	1982-01-01	Xerostomia; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatitis; Primary Myelofibrosis; Osteosarcoma; Cholangitis, Sclerosing; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Epilepsy; Erythema Nodosum; Sarcoma; HIV Wasting Syndrome; Pancreatitis, Chronic; Sarcoma, Ewing; Arachnoiditis; Gastrointestinal Hemorrhage; Retinoblastoma; Prostatic Neoplasms; Endometriosis; Lung Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Myelodysplastic-Myeloproliferative Diseases; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Carcinoma, Hepatocellular; Burning Mouth Syndrome; Stomatitis; Neoplasm Metastasis; Appendiceal Neoplasms; Tuberculosis; Lymphoma, Non-Hodgkin; Angiodysplasia; Pelvic Pain; Glioma; Waldenstrom Macroglobulinemia; Leprosy, Lepromatous; Endometrial Neoplasms; Uterine Neoplasms; Anemia, Sideroblastic; Ovarian Neoplasms; Gastric Antral Vascular Ectasia; Lupus Erythematosus, Discoid; Carc	Details