IL-12A

IL-12A Molekülinformation

Englischer Name	Interleukin-12 subunit alpha	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0	Target-Alias	IL-12A，Cytotoxic lymphocyte maturation factor 35 kDa subunit，CLMF p35，IL-12 subunit p35，NK cell stimulatory factor chain 1，NKSF1
Höchste Forschungs- und Entwicklungsphase	Discontinued

Englischer Name	Interleukin-12 subunit alpha
Target-Alias	IL-12A，Cytotoxic lymphocyte maturation factor 35 kDa subunit，CLMF p35，IL-12 subunit p35，NK cell stimulatory factor chain 1，NKSF1
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0
Höchste Forschungs- und Entwicklungsphase	Discontinued

IL-12A Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
Fc Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
NK1-H5252	Human	HEK293	Human IL-12A / NKSF1 / p35 Protein, Fc Tag				In den Warenkorb legen

Gesamtmenge1

IL-12A Molekülhintergrund

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.

IL-12A Molekülalias

IL12A,CLMF,IL-12A,NFSK,NKSF1,P35

Produktrezensionen

W***A2025-11-07
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Human IL-12A / NKSF1 / p35 Protein, Fc Tag
In IL-2 binding experiments, the affinity constant of this protein with Human IL-2 measured by BLI technology reached 12.3 pM, binding ability is significantly better than the non-biotinylated version.