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StartseiteAlle MoleküleICOS
ICOS
ICOS Molekülinformation
| Englischer Name | Inducible T-cell costimulator | Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 7 | Target-Alias | Activation-inducible lymphocyte immunomediatory molecule，Inducible T-cell costimulator，ICOS，CD278，AILIM，Inducible T Cell Costimulator，Inducible T-Cell Co-Stimulator，Inducible Costimulator，CD278 Antigen，CVID1，Inducible T-Cell Co-Stimulator Protein |
| Höchste Forschungs- und Entwicklungsphase | Phase 2 Clinical | ||
| Englischer Name | Inducible T-cell costimulator |
| Target-Alias | Activation-inducible lymphocyte immunomediatory molecule，Inducible T-cell costimulator，ICOS，CD278，AILIM，Inducible T Cell Costimulator，Inducible T-Cell Co-Stimulator，Inducible Costimulator，CD278 Antigen，CVID1，Inducible T-Cell Co-Stimulator Protein |
| Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 7 |
| Höchste Forschungs- und Entwicklungsphase | Phase 2 Clinical |
ICOS Produktliste
- Attribut
Protein (6)
- Produktbibliothek
Online (6)
- Spezies
Human (3)Mouse (2)Rat (1)
- Etikett
His Tag & Avi Tag (1)Fc Tag (2)His Tag (3)
- Marker
Biotin-labeled (1)Unconjugated (5)
| Produktnummer | Spezies | Expressionssystem | Produktbeschreibung | Proteinstruktur | Reinheit | Eigenschaften | Vorbestellen/Bestellen |
|---|---|---|---|---|---|---|---|
HOT ICS-H5258 |  Human | HEK293 | Human ICOS / CD278 Protein, Fc Tag |  |  |  |  In den Warenkorb legen |
HOT ICS-H52Ha | Human | HEK293 | Human ICOS / CD278 (C136S, C137S) Protein, His Tag, active dimer (MALS verified) | | | In den Warenkorb legen | |
HOT ICS-H82E5 | Human | HEK293 | Biotinylated Human ICOS / CD278 (C136S, C137S) Protein, His,Avitag™ (recommended for biopanning) |  | | | In den Warenkorb legen |
HOT ICS-M52H8 |  Mouse | HEK293 | Mouse ICOS / CD278 (C137S, C138S) Protein, His Tag |  | | | In den Warenkorb legen |
ICS-M5259 | Mouse | HEK293 | Mouse ICOS / CD278 (C137S, C138S) Protein, Fc Tag |  | | | In den Warenkorb legen |
ICS-R52H9 |  Rat | HEK293 | Rat ICOS / CD278 (C137S, C138S) Protein, His Tag |  | | | In den Warenkorb legen |
Gesamtmenge6
- 1
ICOS Molekülhintergrund
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
ICOS Molekülalias
ICOS,CD278,AILIM,Inducible T-cell costimulator
Klinische Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Indikationen | Klinische Studie |
|---|---|---|---|---|---|
| Vopratelimab | JTX-2011 | Phase 2 Clinical | Jounce Therapeutics Inc | Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| Feladilimab | GSK-609; GSK-3359609 | Phase 2 Clinical | Glaxosmithkline Plc | Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Multiple Myeloma | Details |
| Acazicolcept | ALPN-101 | Phase 2 Clinical | Alpine Immune Sciences Inc | Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation | Details |
| MEDI-570 | Phase 1 Clinical | Japan Tobacco (Hong Kong) Ltd | Lymphoma, Follicular; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides | Details | |
| Izuralimab | XmAb-23104; XmAb-104 | Phase 1 Clinical | Xencor Inc | Triple Negative Breast Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Nasopharyngeal Carcinoma; Solid tumours; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell | Details |
| Anti-ICOS (Bristol Myers Squibb) | BMS-986226 | Phase 1 Clinical | Bristol-Myers Squibb Company | Neoplasms | Details |
| anti-ICOS mAb (Bristol-Myers Squibb) | Phase 1 Clinical | Bristol-Myers Squibb Company | Solid tumours; Neoplasms | Details |
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