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FGF-4

FGF-4 Overview

English Name	Fibroblast growth factor 4	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Fibroblast Growth Factor 4 Splice Isoform，Oncogene HST，K-FGF，KFGF，KS3，HBGF-4，Heparin-binding growth factor 4，HST，HSTF1，Fibroblast growth factor 4，FGF4，FGF-4，Transforming Protein KS3，Human Stomach Cancer， Transforming Factor From FGF-Related Oncogene，Heparin Secretory Transforming Protein 1，Kaposi Sarcoma Oncogene，HSTF-1，HST-1，Heparin Secretory-Transforming Protein 1
Highest Development Stage	Phase 3 Clinical

English Name	Fibroblast growth factor 4
Target Synonym	Fibroblast Growth Factor 4 Splice Isoform，Oncogene HST，K-FGF，KFGF，KS3，HBGF-4，Heparin-binding growth factor 4，HST，HSTF1，Fibroblast growth factor 4，FGF4，FGF-4，Transforming Protein KS3，Human Stomach Cancer， Transforming Factor From FGF-Related Oncogene，Heparin Secretory Transforming Protein 1，Kaposi Sarcoma Oncogene，HSTF-1，HST-1，Heparin Secretory-Transforming Protein 1
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 3 Clinical

FGF-4 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
FG4-H51H3	Human	E. coli	Human FGF-4 Protein, His Tag

Total: 1

FGF-4 Background

Fibroblast growth factor-4 (FGF4) is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions. Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. In lung adenocarcinoma (ADC) cell lines, FGF4 could alter cell morphology, promote epithelial-mesenchymal transition-associated protein expression, and enhance cell proliferation, migration/invasion and colony initiation. In B-cell lymphoma, FGF4 secretion by cancer cells induces Jag1 expression in neighbor Endothelial cell that in turn activates Notch2 in lymphoma cells.