DDR1

DDR1 Molekülinformation

Englischer Name	Discoidin domain receptor 1	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5	Target-Alias	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Discoidin domain receptor 1
Target-Alias	Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

DDR1 Produktliste

Attribut
Protein (3)
Produktbibliothek
Online (3)
Spezies
Human (2)Mouse (1)
Etikett
Fc Tag (2)His Tag & Avi Tag (1)
Marker
Unconjugated (2)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT DD1-H82E9	Human	HEK293	Biotinylated Human DDR1 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
DD1-H5258	Human	HEK293	Human DDR1 Protein, Fc Tag	In den Warenkorb legen
DD1-M5259	Mouse	HEK293	Mouse DDR1 Protein, Fc Tag	In den Warenkorb legen

Gesamtmenge3

DDR1 Molekülhintergrund

Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.

DDR1 Molekülalias

CD167a

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Solid tumours; Skin Melanoma; Bone metastases; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Colorectal Neoplasms; Gallbladder Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung	Details
PRTH-101	PRTH-101	Phase 1 Clinical	The George Washington University Milken Institute School Of Public Health (Gwu), Parthenon Therapeutics Inc	Solid tumours; Neoplasms	Details
ICP-033	ICP-033	Phase 1 Clinical	Beijing Innocare Pharma Tech Co Ltd	Solid tumours	Details
AVI-4015	AVI-4015	Phase 1 Clinical	Avixgen	Dry Eye Syndromes	Details
AGX-0073	AGX-0073	Phase 1 Clinical	Shanghai Aojian Biological Technology Co Ltd	Solid tumours	Details